Preheat large griddle or cast-iron skillet over medium-low heat.
Butter one side of each of the slices of bread. Sprinkle Italian seasonings and garlic powder on top. Place one slice of bread buttered-side down. Layer grated cheeses, beef brisket and barbecue sauce on top of bread. Top with another slice of bread buttered-side out.
Place sandwiches onto griddle. Cook on medium-low heat for 3-4 minutes, or until bottom slice of bread is golden brown.
Flip and continue cooking until other side is golden brown and cheese has completely melted.
Notes
Note: If you don’t want to smoke your own brisket, just grab some from a local BBQ restaurant.